Edward Warren, 23, has been living in Thailand for five years, a prodigal son who left his family after an irreparable fight with his father, Luke. There, he learns that his dad lies comatose in a hospital, gravely injured in an accident that has also injured his younger sister Cara.

Cara, 17, still holds a grudge against her brother, since his departure led to her parents' divorce. Cara has lived with her father, an animal conservationist who became famous after living with a wild wolf pack in the Canadian wild. It's impossible for her to reconcile the broken man in the hospital bed with her dynamic father.

With Luke's chances for recovery dwindling, Cara wants to wait for a miracle. But Edward wants to terminate life support and donate his father's organs. Is he motivated by altruism, or revenge? And to what lengths will his sister go to stop him from making an irrevocable decision?

Lone Wolf looks at the intersection between medical science and moral choices. If we can keep people who have no hope for recovery alive artificially, should they also be allowed to die artificially? Does the potential to save someone else's life with a donated organ balance the act of hastening another's death? And finally, when a father's life hangs in the balance, which sibling should get to decide his fate?